The Role and Therapeutic Potential of Interleukin-10 in Immunology

Abstract

One important anti-inflammatory cytokine that is essential for controlling immune responses and avoiding tissue damage brought on by over-activation of the immune system is interleukin-10 (IL-10). Monocytes, macrophages, and regulatory T cells (Tregs) are among the immune cells that secrete it. IL-10 inhibits the activity of antigen-presenting cells, downregulates the expression of co-stimulatory molecules, and suppresses the production of pro-inflammatory cytokines. According to recent research, IL-10 has substantial therapeutic potential for the treatment of a number of chronic and immune-related illnesses, including cancer, viral infections, and autoimmune disorders, in addition to its role as an immune suppressor. However, since IL-10 may also inhibit advantageous immune responses, its therapeutic use necessitates careful modulation. The objectives of this review are to examine the potential clinical uses of IL-10, highlight its dual role in immune regulation, and talk about the difficulties in using it as a therapeutic agent.